Melanotan I 10mg
99.2% HPLC PurityResearch-grade Melanotan I 10mg lyophilised powder. 99.2% HPLC purity, COA verified. Alpha-MSH analogue for pigmentation research.

SKU: PW-010 • Batch: PW-260309
Research-grade Melanotan II 10mg lyophilised powder. 99.1% HPLC purity, COA verified. Cyclic alpha-MSH analogue for pigmentation and tanning research.
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Research-grade Melanotan I 10mg lyophilised powder. 99.2% HPLC purity, COA verified. Alpha-MSH analogue for pigmentation research.
Purity independently verified by an accredited third-party laboratory via HPLC & mass spectrometry.
Melanotan II is a synthetic cyclic analogue of alpha-melanocyte-stimulating hormone (α-MSH). Its cyclic structure, formed by the D-Phe substitution and lactam bridge, confers increased receptor affinity and resistance to enzymatic degradation compared to the native hormone. Supplied at 99.1% HPLC purity with full COA.
Research has explored Melanotan II's activity at MC1R, MC3R, MC4R, and MC5R melanocortin receptor subtypes, producing a broader pharmacological profile than the linear Melanotan I (afamelanotide). Studies have investigated melanogenesis stimulation, pigmentation pathways, and receptor binding kinetics.
The cyclic structure is key to its pharmacological profile. Researchers should distinguish between MT-I (afamelanotide, linear) and MT-II (cyclic) when designing and interpreting research protocols.
Melanotan II is a cyclic α-MSH analogue studied in preclinical research for effects on melanogenesis, pigmentation pathways, and MC receptor activity. For in-vitro laboratory research use only.
Our Melanotan II 10mg is independently verified at 99.1% HPLC purity with full COA documentation.
Store lyophilised at −20°C long term. Once reconstituted with BAC water, store at 2–8°C and use within 4 weeks, protected from light.
Melanotan I is a linear α-MSH analogue with greater MC1R selectivity, while Melanotan II is cyclic with a broader melanocortin receptor binding profile including MC1R, MC3R, MC4R, and MC5R. They are structurally and pharmacologically distinct research compounds.
Melanotan II 10mg is sold strictly for in-vitro laboratory and research purposes only. This product is not intended for human consumption, therapeutic use, cosmetic use, or veterinary application. You must be 18 years of age or older to purchase. By purchasing, you confirm that you are a qualified researcher and will use this product in compliance with all applicable laws and regulations.
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Recent peer-reviewed studies from PubMed related to Melanotan II. Provided for research context — not medical advice.
Melanotan II: a possible cause of renal infarction: review of the literature and case report
Peters B, Hadimeri H, Wahlberg R, et al. · CEN case reports · 2020
PMID: 31953620
Melanotan-II reverses memory impairment induced by a short-term HF diet
Wekwejt P, Wojda U, Kiryk A · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
PMID: 37478579
Melanotan II User Experience: A Qualitative Study of Online Discussion Forums
Gilhooley E, Daly S, McKenna D · Dermatology (Basel, Switzerland) · 2021
PMID: 34464955
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists
Tomassi S, Dimmito MP, Cai M, et al. · Journal of medicinal chemistry · 2022
PMID: 35188390
Source: U.S. National Library of Medicine (PubMed). Citations are fetched live and cached; inclusion does not imply endorsement of any therapeutic use.